Can Argireline™ and Vitamin C Be Used Together?

Both Vitamin C and peptides have long been adored by those in the industry for their positive effects when being included in skincare routines. While Vitamin C improves the skin’s barrier and helps to prevent dark spots, peptides are made up of amino acids and proteins naturally found in the body.

As we age, these become less common in the body and we must resort to skincare products to make up for the loss in production. These proteins and acids are vital to increasing the presence of collagen and elastin in the skin, which prevents aging signs and the appearance of dull skin.

Though these ingredients work wonders on their own, what about when they are mixed? Argireline™ being one of the most popular peptides on the market, do these ingredients provide the same results when blended or are they better left being used solo?


Yes, depending on your skin. It isn’t recommended to directly mix ascorbic acid (the pure form of Vitamin C) with peptides such as Argireline™. Vitamin C tends not to combine well with skincare ingredients such as niacinamide and retinoids.

When combining these two ingredients, it is beneficial to keep in mind their stability. Vitamin C can be unstable and prone to oxidation, especially when exposed to light and air. This can ultimately reduce its effectiveness. Therefore, it's important to use stable forms of vitamin C, such as ascorbic acid, that have a longer shelf life and are less likely to degrade when exposed to other ingredients.

Another factor to consider when mixing the two ingredients is their pH levels. Vitamin C is most effective at a pH level below 3.5, while Argireline™ may require a higher pH level to remain stable. If you are formulating your skincare product, it's essential to ensure that the pH levels of the ingredients are compatible to maintain their effectiveness.

That being said, Vitamin C derivatives are considered to be a safer alternative rather than using the direct, pure form of the antioxidant when mixing with Argireline™ formulas. There haven’t been enough adverse reactions regarding the THD (liquid or fat-soluble) version of Vitamin C, nor is there enough research out there to fully state that mixing the two ingredients is unsafe.

Before applying any new skincare combination to your face, it is always recommended to perform a patch test. Apply a small amount of the mixture to a small area of your skin, such as the inner arm, and observe for any adverse reactions or sensitivities. If you experience any redness, irritation, or discomfort, it's best to avoid using the mixture on your face.



Nobody loves Vitamin C more than we do. It’s understandable if you still want to reap the benefits of ascorbic acid and peptides. To get the most out of your skincare products, it’s best to avoid using Vitamin C and Argireline™ during the same cycle.

Instead, many experts and users recommend alternating your routines, by either time of day or different days entirely. What’s convenient about Argireline™ is the peptide can be applied either in the AM or PM, so you may use Vitamin C during your AM routine and Argireline™ before you go to bed.

When it comes to skin health, we know a thing or two. Vitamin C and peptides are both ingredients that are worth looking into if they’re not a part of your skincare collection already.

Beginning with a staple antioxidant for any user, Vitamin C is a favorite of dermatologists and experts in the industry for a variety of reasons. Its versatile benefits include early prevention of aging signs, sun damage prevention/treatment, acne treatment, and even the ability to help with conditions such as hyperpigmentation.

This particular formula contains a mixture of antioxidants to give you that extra boost of barrier protection and prevention of aging woes such as fine lines and dark spots. Recommended for all skin types, particularly those with sensitive prone skin, the serum can be applied up to twice daily and its effects are even more powerful when combined with our Dark Spot Correcting N.A.T. Formula Serum.


A clinically-tested formula, this peptide complex serum perfectly blends a 10% concentration of Argireline™ that seamlessly integrates into skincare regimens. This complex peptide targets dynamic wrinkles, preventing muscle movements that lead to the formation of aging signs.

This results in firmer, smoother, and youthful-looking skin. The peptide gets assistance from other ingredients such as Vitamin E and vita-polypeptide to secure moisture in the skin and provide an enhanced barrier to prevent free radicals from damaging the skin.


An eye cream that also utilizes the powerful effects of the peptide Argireline™, the nourishing formula provides a lightweight texture that can effortlessly be incorporated into skincare routines, no matter your skin type. Its lightweight formula allows for deeper moisturization below the skin’s surface and full hydration and rejuvenation.

With the option to apply to your AM or PM routine (or both), this cream is specifically suited for the area around the eyes, where the skin is thinner and more sensitive to formulas. This area is often prone to showing early signs of aging, so applying the peptide to this area will help prevent the appearance of crow’s feet, fine lines, and dull skin.


Are you a fan of face masks or eye patches? Who isn’t? Not only are they convenient for traveling, as they don’t count as liquids, but they come with a laundry list of benefits for the skin. Try following up your skincare routine with micro dart patches, a revolutionary formula that continues to astound experts and users worldwide with its moisturizing properties.

The unique serum formulation of active ingredients hyaluronic acid, Argireline™, amino acids, and trehalose all come together to thwart aging signs. These acids, antioxidants, and synthesized molecules in the formula are all naturally found in the skin, their enhanced presence allowing the skin to further protect itself from factors such as free radicals and environmental damage.

The best part? Forget waiting weeks or even months for results. You’ll instantly see improvements in the applicable area within 24 hours.



Conclusion: can you mix argireline with vitamin c

Mixing Argireline™ and Vitamin C should generally be safe, but it is important to consider a few factors. Argireline™ is a peptide that is commonly used in skincare products for its anti-aging effects, particularly in reducing the appearance of wrinkles and fine lines. Vitamin C, on the other hand, is a potent antioxidant known for its ability to brighten the skinand even out skin tone.

It's worth noting that individual responses to skincare ingredients can vary, and it's always a good idea to consult with a dermatologist or skincare professional who can provide personalized advice based on your specific needs and skin type.