Can I Use Matrixyl with Retinol?

Like french fries dipped in ice cream, two ingredients that are excellent on their own, but when paired, it just works. It's a surprise to discover various skincare chemicals that you may add and blend into your program to help your skin.

However, in your continuing mission to make your skincare routine as effective as possible—not to mention get the most bang for your buck from the products you use—understanding which chemicals work well together may be advantageous.

On the other hand, certain combinations do not combine well and can result in either inactivation or severe skin irritation, neither of which you desire. To keep things easy, consider the list below a 'cheat sheet' of items that pair very well—and those that don't.

Can I Use Matrixyl With Retinol?

Yes you can, we recommend that if you have sensitive skin you should apply each component of your skincare regimen on different days or at different times of the day for the best results and to avoid undesirable side effects. Because matrixyl and retinol both increase skin cell turnover, so it is very vital to use a daily SPF to protect the face from free radicals such as UV radiation, pollution, central heating, and other environmental aggressors after applying these ingredients.

This will allow you to reap the benefits of the two superstars in the skincare industry and prevent from any sun sensitivity and skin irritation. However, we discovered that using Matrixyl with any form of Acid or Vitamin C together that can cause harm and discomfort should be avoided at all cost.

How to Layer Matrixyl with retinol?

  1. Our Matrixyl 3000 is a serum based product that you apply to your skin after cleansing and exfoliating to increase collagen production.
  2. This Matrixyl® 3000 Serum works in tandem with our revolutionary Micro Dart Patches to achieve the best results for fine lines and wrinkles around the eyes.
  3. To maximise the anti-aging effects of the items, use your Retinol night cream to seal in the nutrients from your serum and patches.

Yet another buzz ingredient making headlines in the cosmetics business, matrixyl is one new kid on the block that we could all use. As I type this, I can hear your questions racing through your mind; don't worry, I'll clear things up by the end of today's blog post.

Find out more on Matrixyl's Orgin from us : Matrixyl and how it benefits the skin.


Is Matrixyl the same as retinol?

Matrixyl's clinical trial outcomes are comparable to, if not superior to, those of retinol.
Matrixyl, unlike retinol, is less likely to produce irritation and harmful skin side effects such as increased risk of UV damage.

There's no need to get rid of your retinol or retinoid products if you've been using them for a while. Matrixyl and retinols complement each other wonderfully. Look for a Matriyxl 3000 product that targets other skin issues to supplement your retinol's efforts.

Retinol is often used as a serum but we've created a Anti-Aging Retinol Night Cream that finishes and moisturized your face at night before you sleep.

The Feeling of Envy: Matrixyl 3000 is used to treat the eye area, which can be too sensitive for hard-hitting retinols.

Another bonus to using matrixyl is the fact that anyone can use it. The only concern you may have been ensuring your skin is happy with the other ingredients it’s blended with.

Read here on our other blog "Is Matrixyl Better Than Retinol? "

What can you not mix with matrixyl?

As beneficial as matrixyl is to the skin, it does come with certain risks due to the presence of other chemicals such as vitamin C, commonly known as L-ascorbic acid, BHA, such as salicylic acid, and other acids, such as the popular AHA, glycolic acid.

It is recommended that you avoid using these components together due to the over-exfoliation that will result if you do. Although matrixyl is deemed safe for usage on all skin types, it is crucial to understand that matrixyl operates on the skin in a manner similar to retinol. While the substance does not technically exfoliate the skin by accelerating skin cell turnover, if you apply an exfoliating formulation on top of it, you will overstimulate the skin, induce pH imbalance, and result in flare-ups and redness. See your Dermatologist if this happeneds.

avoid pairing Matrixyl with different types of acids

Both Glycolic and Salicylic Acid are excellent exfoliators, so it’s not necessary to use them at the same time. They achieve different goals, Glycolic Acid is better for reducing fine lines whereas Salicylic Acid is better for acne so if you do need to use both, use them at separate times. Lactic Acid is known as the gentler version of Glycolic Acid, so it’s redundant to use both and would only increase the risk of skin sensitivity.

Lactic Acid With Salicylic Acid + Matrixyl

Since Lactic Acid is an exfoliator like Salicylic Acid, avoid using them together. Matrixyl is like the baby version of Retinol and doesn’t play well with acids, so it’s recommended to not layer with Lactic Acid. These ingredients are also effective on their own, so try them separately and with a hydrating moisturizer to seal them in.

Can i use matrixyl and niacinamide together?

Yes, combining niacinamide and peptides is deemed entirely safe. Using a combination of these two powerhouses will result in the skin's lipid barrier retaining the proper levels of water and oil, strengthening it and allowing it to protect the skin's surface from dangerous free radical damage.

Read about niacinamide in our Micro Dart Patches Ingredients to give you more indepth on why matrixyl 3000 is the perfect serum that works in partnership with our under-eye patches.

You now have a basic understanding of how to combine niacinamide with matrixyl.
Even if you've been using these components for a while and have a well-established regimen, it's always a good idea to talk with a doctor or dermatologist to verify you're utilizing the optimum ingredients for you and your skin's needs.

Can i use Argireline™ and retinol together?

Yes, but be cautious about when and how you use it due to the great potency of these two substances, employing Argireline™ and retinol together requires some careful thought and consideration. Many skin experts say that, as beneficial as peptides are to the skin, they penetrate too deeply into the lower layers. This can benefit many people with oily or combination skin, but it can cause skin irritation and severe dryness in those with dry or sensitive skin.

Argireline™, also known as the "needle-free alternative to Botulinum Toxin," is a reduced version of the botulinum toxin contained in Botulinum Toxin. It is a peptide that works similarly to many wrinkle treatments on the market today. That's why we've created a non invasive anti-aging product that has these key elements to target fine lines and wrinkes under the thin layers of your eyes to produce collagen for ever lasting glowing and plumping skin.

Those who are looking to treat fine lines, undereye wrinkles, forehead creases and even laugh lines should look to argerline over retinol as it is effective and gentler on the skin.

If you are worried about combining Argireline™ and retinol, you can alternate when you apply each of these substances, ideally saving retinol for your evening routine because UV exposure renders the strong vitamin A worthless and ineffectual at delivering its results.


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conclusion : can i use matrixyl 3000 with retinol?

Yes, we
advocate applying each component of your skincare regimen on various days or at different times of the day if you have sensitive skin to get the best results and to avoid negative effects. Depology recommends using matrixyl and retinol at night due to retinols can make the skin more sensitive to the damaging rays of the sun. This will make it easier for you to benefit from the two powerful ingredients. But remember to avoid using Matrixyl with any of the types of Acid or Vitamin C that can be harmful to skin irratation.

With the combination of Argireline™ and Matrixyl 3000, you get the affects of Argirelines retraining and relaxing of muscles and the improvement of pliable skin to greatly reduces and eliminate wrinkles and fine lines. At Dēpology we have products that can help you mix and match products that can easily be incorporated into your skincare routine.

If you have any further questions follow our Socials @DepologySkincare on Instagram for more information that can help benefit your skin or shoot us a DM and don't hesitate to ask us questions! We are more than happy to help you on your skincare journey!